abstract：BACKGROUND:Preoperative injection of radiocolloid before a sentinel lymph node (SLN) biopsy is painful for patients with breast cancer. Injection after anesthesia eliminates this discomfort but allows less time for radiocolloid migration. Our goal was to validate the efficacy of intraoperative injection. METHODS:In th...

journal_title：Annals of surgical oncology

authors： Stell VH,Flippo-Morton TS,Norton HJ,White RL Jr

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:The clinical significance of isolated tumor cells (ITC) in peripheral blood (PB) and bone marrow (BM) as predictive markers in the recurrence or metastasis of breast cancer has not yet been determined. In the current study, we focused on the urokinase plasminogen activator receptor (u-PAR) gene as a powerf...

journal_title：Annals of surgical oncology

authors： Mimori K,Kataoka A,Yamaguchi H,Masuda N,Kosaka Y,Ishii H,Ohno S,Mori M

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dickkopf-1 (DKK1) is the inhibitor of the canonical Wnt signaling pathway, however it is highly transactivated in various cancers, suggesting the presence of unknown mechanism. Its implication in human esophageal squamous cell carcinoma (ESCC) has not been sufficiently investigated. PATIENTS ...

journal_title：Annals of surgical oncology

authors： Makino T,Yamasaki M,Takemasa I,Takeno A,Nakamura Y,Miyata H,Takiguchi S,Fujiwara Y,Matsuura N,Mori M,Doki Y

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Experimental studies have revealed that D2-40 is useful in identifying the presence of lymphatic invasion in various malignant neoplasms, but the clinical significance remains unclear. The purpose of this study is to assess the clinical significance of D2-40 status in completely resected non-small cell lung ...

journal_title：Annals of surgical oncology

authors： Iwakiri S,Nagai S,Katakura H,Takenaka K,Date H,Wada H,Tanaka F

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:Atypical protein kinase C iota (aPKC-iota) and its associated intracellular molecules, E-cadherin and beta-catenin, are important for cell polarization in tumorigenesis and progression. Expression of aPKC-iota, P-aPKC-iota (activated aPKC-iota), E-cadherin, and beta-catenin in hepatocellular carcinoma (HCC) ...

journal_title：Annals of surgical oncology

authors： Du GS,Wang JM,Lu JX,Li Q,Ma CQ,Du JT,Zou SQ

更新日期：2009-06-01 00:00:00

abstract：:Tumors treated with preoperative chemotherapy or radiation often demonstrate evidence of response in the resection specimen. Pathologic response is often interpreted as a surrogate for recurrence or survival outcomes. With a valid surrogate for long-term outcomes, investigators can explore treatment strategies with im...

journal_title：Annals of surgical oncology

authors： Mansour JC,Schwarz RE

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with significantly longer survival in patients with peritoneal carcinomatosis (PC). So far, no morphological imaging method has proven to accurately assess the intra-abdominal tumor spread. This study was design...

journal_title：Annals of surgical oncology

authors： Pfannenberg C,Königsrainer I,Aschoff P,Oksüz MO,Zieker D,Beckert S,Symons S,Nieselt K,Glatzle J,Weyhern CV,Brücher BL,Claussen CD,Königsrainer A

更新日期：2009-05-01 00:00:00

abstract：:Preoperative needle diagnosis (PND) is being considered as a quality measure in breast cancer surgery. This criterion has not been thoroughly evaluated in the literature. The purpose of this study is to assess ease of access to these data and rate of compliance in a tertiary care center. We retrospectively reviewed al...

journal_title：Annals of surgical oncology

authors： Pocock B,Taback B,Klein L,Joseph KA,El-Tamer M

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase 7 (MMP-7) is involved in invasion, metastasis, growth, and angiogenesis. The aim of this study is to assess the prognostic role of serum MMP-7 in curatively resected colorectal cancer (CRC). MATERIALS AND METHODS:Patients undergoing resection for CRC (n = 175) were recruited from Ju...

journal_title：Annals of surgical oncology

authors： Martínez-Fernandez A,García-Albeniz X,Pineda E,Visa L,Gallego R,Codony-Servat J,Augé JM,Longarón R,Gascón P,Lacy A,Castells A,Maurel J

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:The extent of neck dissection (ND) appropriate for necks yielding clinical evidence of metastases of papillary thyroid carcinoma (PTC) is controversial. The need for level IIb lymph node (LN) dissection is particularly uncertain in view of its association with postoperative shoulder dysfunction. In the prese...

journal_title：Annals of surgical oncology

authors： Koo BS,Yoon YH,Kim JM,Choi EC,Lim YC

更新日期：2009-05-01 00:00:00

abstract：INTRODUCTION:Actual 5-year survival rates of 10-18% have been reported for patients with resected pancreatic adenocarcinoma (PC), but the use of multimodality therapy was uncommon in these series. We evaluated long-term survival and patterns of recurrence in patients treated for PC with contemporary staging and multimo...

journal_title：Annals of surgical oncology

authors： Katz MH,Wang H,Fleming JB,Sun CC,Hwang RF,Wolff RA,Varadhachary G,Abbruzzese JL,Crane CH,Krishnan S,Vauthey JN,Abdalla EK,Lee JE,Pisters PW,Evans DB

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:After introduction of the clamp-crushing technique in the 1970s, various devices have been developed for transection of the liver with the aim of further reducing blood loss and improving the outcome of patients who undergo hepatic resection. We performed a meta-analysis to quantitatively compare the clamp-c...

journal_title：Annals of surgical oncology

authors： Rahbari NN,Koch M,Schmidt T,Motschall E,Bruckner T,Weidmann K,Mehrabi A,Büchler MW,Weitz J

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Groin wound breakdown, lymphoceles, cellulitis, and chronic leg edema are the most frequent complications of inguinal lymphadenectomy, resulting in severe patient discomfort and significant lengthening of postoperative stay. Despite all innovations, complication rates are still high and inevitable. Our exper...

journal_title：Annals of surgical oncology

authors： Manci N,Marchetti C,Esposito F,De Falco C,Bellati F,Giorgini M,Angioli R,Panici PB

更新日期：2009-03-01 00:00:00

abstract：:There is increasing evidence regarding extracapsular lymph node involvement (LNI) as a prognostic factor for recurrence and poor prognosis in gastrointestinal malignancies. The aim of this study was to assess the prevalence and prognostic impact of LNI in patients with resected esophageal cancer, comparing adenocarcin...

journal_title：Annals of surgical oncology

authors： Metzger R,Drebber U,Baldus SE,Mönig SP,Hölscher AH,Bollschweiler E

更新日期：2009-02-01 00:00:00

abstract：:The purpose of this study was to clarify the outcome of the ratio between metastatic and examined lymph nodes (N ratio) in gastric cancer patients with < or =15 examined lymph nodes after D2 lymphadenectomy. A retrospective study was performed in 906 patients with gastric cancer who had undergone D2 resection. Patient...

journal_title：Annals of surgical oncology

authors： Xu DZ,Geng QR,Long ZJ,Zhan YQ,Li W,Zhou ZW,Chen YB,Sun XW,Chen G,Liu Q

更新日期：2009-02-01 00:00:00

abstract：:Isolated hepatic perfusion (IHP) is a proven approach for regional delivery of chemotherapy in patients with unresectable primary and metastatic tumors of the liver. Most trials of IHP have utilized melphalan as the active drug in the perfusate. We performed a phase I trial to evaluate the efficacy, safety, and maximu...

journal_title：Annals of surgical oncology

authors： Zeh HJ 3rd,Brown CK,Holtzman MP,Egorin MJ,Holleran JL,Potter DM,Bartlett DL

更新日期：2009-02-01 00:00:00

abstract：:Genetic polymorphisms play an important role in clinical response to cytotoxic therapies. We hypothesized that polymorphisms in cell cycle genes may modulate response to preoperative chemoradiation and survival of pancreatic cancer patients. We evaluated 12 single-nucleotide polymorphisms (SNPs) of ten cell cycle gene...

journal_title：Annals of surgical oncology

authors： Chen J,Li D,Killary AM,Sen S,Amos CI,Evans DB,Abbruzzese JL,Frazier ML

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:In 2003, the American Joint Committee on Cancer (AJCC) initiated the 6th edition staging criteria, including pN0(i+) and pN1mi categories for breast cancer. However, the clinical significance of these categories is debated in the literature. METHODS:A prospective registry was used to identify patients stage...

journal_title：Annals of surgical oncology

authors： Pugliese MS,Beatty JD,Tickman RJ,Allison KH,Atwood MK,Szymonifka J,Arthurs ZM,Huynh PP,Dawson JH

更新日期：2009-01-01 00:00:00

abstract：:Information is lacking regarding the interaction of established breast cancer risk factors and patient age. We attempted to study this interaction in high-risk women at the extremes of age in our population. The Women-At-Risk Registry was queried for women who were < or =35 and > or =70 years of age. Enrollment criter...

journal_title：Annals of surgical oncology

authors： Chun J,Pocock B,Joseph KA,El-Tamer M,Klein L,Schnabel F

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Noninvasive thermal ablation using magnetic resonance (MR)-guided focused ultrasound (MRgFUS) has been shown to be clinically effective in uterine fibroids, and is being evaluated for ablation of breast, liver, and brain lesions. Recently MRgFUS has been evaluated for palliation of pain caused by bone metast...

journal_title：Annals of surgical oncology

authors： Liberman B,Gianfelice D,Inbar Y,Beck A,Rabin T,Shabshin N,Chander G,Hengst S,Pfeffer R,Chechick A,Hanannel A,Dogadkin O,Catane R

更新日期：2009-01-01 00:00:00

abstract：:The purpose of this study was to determine the outcome of surgery for patients with recurrent gastric or gastroesophageal cancer. We queried records from 7,459 patients who presented with gastric or gastroesophageal cancer to our institution from 1973 through 2005 to identify those for whom resection of recurrent dise...

journal_title：Annals of surgical oncology

authors： Badgwell B,Cormier JN,Xing Y,Yao J,Bose D,Krishnan S,Pisters P,Feig B,Mansfield P

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Many cytotoxic drugs maintain antiangiogenic properties, but there are no human, tumor-based assays to evaluate their antiangiogenic potential. We used a fibrin-thrombin clot-based angiogenesis model to evaluate the angiogenic response of human breast cancer to various cytotoxic agents commonly used in its t...

journal_title：Annals of surgical oncology

authors： Lyons JM 3rd,Anthony CT,Thomson JL,Woltering EA

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The aim of this clinical study was to evaluate quality of life (QoL) in early-stage breast cancer patients and to investigate the effects of a comprehensive rehabilitation program comparing women undergoing sentinel node biopsy (SNB) versus complete axillary lymph node dissection (ALND). QoL was assessed wit...

journal_title：Annals of surgical oncology

authors： Pinto e Silva MP,Sarian LO,Morais SS,Pace do Amaral MT,Freire de Oliveira MM,Derchain S

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Dysregulation of apoptosis is a key factor in carcinogenesis and tumor progression. X-linked inhibitor of apoptosis (XIAP) is the most potent member of the inhibitor of apoptosis protein (IAP) family, which directly inhibits apoptosis by binding to caspases. Antagonists of XIAP have recently been identified:...

journal_title：Annals of surgical oncology

authors： Shibata T,Noguchi T,Takeno S,Gabbert HE,Ramp U,Kawahara K

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Despite advancements in radiologic imaging and minimally invasive surgery, the evaluation and management of insulinomas is institution and surgeon dependent. Therefore, the reported surgical outcomes are highly variable. We compared the surgical management and outcomes of insulinomas between two internationa...

journal_title：Annals of surgical oncology

authors： Roland CL,Lo CY,Miller BS,Holt S,Nwariaku FE

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The goal of this study is to report the safety and efficacy of pancreatic resection for isolated metastatic cancers from nonpancreatic primary disease. METHODS:We retrospectively identified patients from a single institution's prospectively gathered pancreaticobiliary database from 1970 to 2007 who underwen...

journal_title：Annals of surgical oncology

authors： Reddy S,Edil BH,Cameron JL,Pawlik TM,Herman JM,Gilson MM,Campbell KA,Schulick RD,Ahuja N,Wolfgang CL

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Carcinomatosis of colorectal origin is increasingly treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS-HIPEC). This procedure commonly involves multivisceral resection (MVR) with potentially high morbidity. We analyzed the effect of MVR on the outcome after CS-HIPEC. METHODS:...

journal_title：Annals of surgical oncology

authors： Franko J,Gusani NJ,Holtzman MP,Ahrendt SA,Jones HL,Zeh HJ 3rd,Bartlett DL

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Gemcitabine has been shown to exhibit significant clinical activity against pancreatic cancer and has become a first-line chemotherapeutic for this disease in recent years. However, there are still many patients who do not respond to this treatment and it is expected to improve the clinical outcome if we can...

journal_title：Annals of surgical oncology

authors： Takano S,Togawa A,Yoshitomi H,Shida T,Kimura F,Shimizu H,Yoshidome H,Ohtsuka M,Kato A,Tomonaga T,Nomura F,Miyazaki M

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Patients with resected extrahepatic bile duct adenocarcinoma who have microscopically positive resection margins and/or pathologic locoregional nodal involvement (R1pN1) have a high-risk of locoregional recurrence, and therefore, we advocate the use of adjuvant chemoradiation. To evaluate the safety and effe...

journal_title：Annals of surgical oncology

authors： Borghero Y,Crane CH,Szklaruk J,Oyarzo M,Curley S,Pisters PW,Evans D,Abdalla EK,Thomas MB,Das P,Wistuba II,Krishnan S,Vauthey JN

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Lymph node involvement is a very important prognostic factor for cutaneous melanoma. In this paper we try to validate a nomogram that was created at the Memorial Sloan-Kettering Cancer Center, New York, to predict the probability of metastases in the sentinel nodes of patients with cutaneous melanoma. METHO...

journal_title：Annals of surgical oncology

authors： Piñero A,Canteras M,Ortiz E,Martínez-Barba E,Parrilla P

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Functional chemokine receptors are expressed in many malignant tumors, including papillary thyroid carcinoma (PTC). These receptors promote tumor growth and metastasis in response to endogenous chemokines. The purpose of this study was to examine the expression of two chemokine receptors-CXCR4 and CCR7-in a ...

journal_title：Annals of surgical oncology

authors： Wagner PL,Moo TA,Arora N,Liu YF,Zarnegar R,Scognamiglio T,Fahey TJ 3rd

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:Lymphadenectomy and thyroidectomy is standard treatment for medullary thyroid carcinoma (MTC), but the prognostic importance of the number of lymph nodes removed (lymph node yield, LNY) and the proportion of metastatic lymph nodes resected (metastatic lymph node ratio, MLNR) is unknown. We hypothesized tha...

journal_title：Annals of surgical oncology

authors： Leggett MD,Chen SL,Schneider PD,Martinez SR

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:We present an alternative access technique to facilitate preperitoneoscopic (extraperitoneal laparoscopic) approach for radical prostatectomy, herniorrhaphy, and other pelvic procedures. METHODS:A 0 degrees telescope was mounted into a Visiport Optical Trocar (Visiport), and via a periumbilical incision it ...

journal_title：Annals of surgical oncology

authors： Tai HC,Lai MK,Chueh SC,Chen SC,Hsieh MH,Yu HJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Breast-conserving surgery (BCS) requires clear surgical margins to minimize local recurrence. We sought to identify groups of patients at higher risk of involved margins who might benefit from preoperative counselling and/or more generous excision at the first operation. METHODS:We reviewed demographic, cli...

journal_title：Annals of surgical oncology

authors： Kurniawan ED,Wong MH,Windle I,Rose A,Mou A,Buchanan M,Collins JP,Miller JA,Gruen RL,Mann GB

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Clinical practice guidelines have been developed to improve melanoma patient care. However, it is unclear whether failure to comply with these standards (either excessive or inadequate treatment) increases morbidity or relapse rates. Therefore, we undertook this study to evaluate the effect of variance from ...

journal_title：Annals of surgical oncology

authors： Erickson Foster J,Velasco JM,Hieken TJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Subtotal thyroidectomy or lobectomy without radioactive iodide ((131)I) treatment is sufficient for postoperative treatment of incidental papillary thyroid microcarcinoma (PTMC). Aggressive surgical treatment with (131)I therapy is indicated for nonincidental PTMC. METHODS:This is a retrospective analysis o...

journal_title：Annals of surgical oncology

authors： Lin JD,Kuo SF,Chao TC,Hsueh C

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Touch imprint cytology (TIC) is a fast, cheap and specific intraoperative examination of the sentinel lymph nodes (SLNs) in early breast cancer patients. The results of TIC in patients with ultrasonically (US) uninvolved axillary lymph nodes are not known. The objective of our study was to compare the result...

journal_title：Annals of surgical oncology

authors： Perhavec A,Besić N,Hocevar M,Zgajnar J

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Although the honeycomb microcystic type is common and typical for a serous cystic tumor (SCT), clinical and radiological features are diverse. Systematic classification of SCT subtypes is not well established. The purpose of this study was to classify the subtypes of SCT and to clarify its clinical and patho...

journal_title：Annals of surgical oncology

authors： Lee SE,Kwon Y,Jang JY,Kim YH,Hwang DW,Kim MA,Kim SH,Kim SW

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Isolated limb infusion (ILI) is a recently described minimally invasive technique developed in Australia for delivering regional chemotherapy. This study examined the efficacy and toxicity of ILI, compared to hyperthermic isolated limb perfusion (HILP), in treating extremity in-transit melanoma. METHODS:Var...

journal_title：Annals of surgical oncology

authors： Beasley GM,Petersen RP,Yoo J,McMahon N,Aloia T,Petros W,Sanders G,Cheng TY,Pruitt SK,Seigler H,Tyler DS

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:COX inhibitors and beta-blockers were recently suggested to reduce cancer progression through inhibition of tumor proliferation and growth factor secretion, induction of tumor apoptosis, and prevention of cellular immune suppression during the critical perioperative period. Here we evaluated the perioperativ...

journal_title：Annals of surgical oncology

authors： Benish M,Bartal I,Goldfarb Y,Levi B,Avraham R,Raz A,Ben-Eliyahu S

更新日期：2008-07-01 00:00:00